Plot items (Origins)

Some quest will require you to retrieve an item(s) from a specific location. Iron Bark is one item almost everyone will find and complete, since there is only one of these and is found while in progress of another quest. Love letters on the other hand are not as easy to find. There are 12 of these in the game. Once you pick them up, you can not remove them from your inventory until you have all 12 and turn them into the bar tender who gave you the initial quest.